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Olanzapine induced neuroleptic malignant syndrome—a case review

✍ Scribed by Aleš Kogoj; Ingrid Velikonja

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
79 KB
Volume
18
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

Neuroleptic malignant syndrome is the rarest and the most serious of the neuroleptic induced movement disorders. Although potent neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs may also be a cause of NMS. Three databases were searched using the terms ‘olanzapine’ and ‘neuroleptic’ ‘malignant syndrome’. Case reports were selected and reviewed from among all articles that fulfilled the search criteria. Twenty six cases were reviewed. Twenty cases fulfilled the criteria published by Sachdev et al. Olanzapine was the most probable cause of NMS in 16 cases. The absence of rigidity was described in only two of 16 highly probable olanzapine induced NMS cases, which is not as often as it is reported in clozapine associated NMS (36%). It was found that prior NMS is an important risk factor in NMS. Copyright © 2003 John Wiley & Sons, Ltd.

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