OL-003 Genetic changes in the interferon sensitivity determining region of hepatitis C virus during the natural course of chronic hepatitis C 3a may lead to non-response to interferon therapy
✍ Scribed by A. Raza; J. Asad; N. Zaman; H. Aziz; S. Murtaza; J. Irfan
- Book ID
- 118617715
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 160 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1201-9712
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## Abstract The degree of variability of the interferon sensitivity determining region (ISDR) in the hepatitis C virus (HCV) genome has been postulated to predict the response to interferon therapy, mainly in patients infected with subtype 1b, although this prediction has been the subject of a long
Two genomic regions of hepatitis C virus (HCV), the interferon sensitivity-determining region (ISDR) of the non-structural 5A gene (NS5A) and the protein kinase-RNA activated (PKR)-eukariotic transcription factor (eIF2-alpha) phosphorylation homology domain (PePHD) of the structural E2 gene, interac
## Abstract The interferon sensitivity‐determining region (ISDR) is thought to be inhibited by the double‐stranded RNA‐dependent protein kinase (PKR). Several studies have reported a relationship between the ISDR and interferon (IFN) responsiveness. However, this relationship is controversial. The