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Okadaic acid induces sustained activation of NFκB and degradation of the nuclear IκBα in human neutrophils

✍ Scribed by Veronika Miskolci; Susana Castro-Alcaraz; Peter Nguyen; Ales Vancura; Dennis Davidson; Ivana Vancurova

Book ID
117042637
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
331 KB
Volume
417
Category
Article
ISSN
0003-9861

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## Abstract Nuclear factor‐kappa B (NF‐κB) is an essential transcription factor in the control of expression of genes involved in cell growth, differentiation, inflammation, and neoplastic transformation. Previously, we reported that okadaic acid (OA), which is a specific inhibitor of serine/threon