𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Offsetting toxicity of antineoplastic agents

✍ Scribed by Dr. Elton S. Cook; Leo G. Nutini; John C. Fardon; M. Agnes Bernadette Proudfoot; M. Eymard Poydock

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
397 KB
Volume
7
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

PCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions. In vivo, PCO enhances the action of methotrexate against the L‐1210 lymphoid leukemia and does not interfere with the effectiveness of fluorouracil against the ascites Krebs‐2 tumor.

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