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Oestrogenic Compounds Modulate Cytokine-induced Nitric Oxide Production in Mouse Osteoblast-like Cells

โœ Scribed by RUTGER L. VAN BEZOOIJEN; CHRIS VAN DER BENT; SOCRATES E. PAPAPOULOS; CLEMENS W. G. M. LOWIK


Book ID
111769902
Publisher
Pharmaceutical Press
Year
1999
Tongue
English
Weight
343 KB
Volume
51
Category
Article
ISSN
2042-7158

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Nitric oxide (NO) produced by endothelial cells (EC) has been shown to exert cytotoxic activity on tumor cells. In order to analyze events involved in brain metastasis, the modulation of N O production in rat-brain-derived EC was investigated. N O release was increased by tumor necrosis factor-a (TN