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Odor–Structure Relationships Using Fluorine as a Probe

✍ Scribed by Dominique Michel; Manfred Schlosser

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
138 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

AbstractÐEight ethers, nine esters and one ketone were submitted to a systematic structural variation by replacing a hydrogen atom in the vicinity of the oxofunction by ¯uorine and methyl. As long as steric factors dominate, a ¯uorine substituent alters the olfactory properties of the parent compound much less than a methyl substituent does. However, if it occupies a position adjacent to a carbonyl group, the halogen may more profoundly affect the odor perception, presumably as a consequence of conformational changes.

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