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Odoriferous Cyclic Ethers via Co-Halogenation Reaction: Facile Preparation of Nerol Oxide, Florol®, Florol® Methyl Ether, and Pityol® Methyl Ether

✍ Scribed by Pankaj Gupta; Vijay K. Sethi; Subhash C. Taneja; Bhahwal A. Shah; Samar S. Andotra; Surrinder Koul; Swapandeep S. Chimni; Ghulam N. Qazi


Book ID
102254770
Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
106 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis


A series of odoriferous cyclic ethers, including nerol oxide (1), Florol (2), Florol methyl ether (3), and Pityol methyl ether (4b), were prepared by a versatile synthetic protocol based on co-halogenation with 1,3-dibromo-5,5-dimethylhydantoin (= 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; DDH) as the key step. The methodology provides a facile access to important perfumery molecules from abundantly available monoterpene alcohols.