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Octapeptide Analogs of Somatostatin Containing α,α-Dialkylated Amino Acids with Potent Anticancer Activity

✍ Scribed by Sudhanand Prasad; Archna Mathur; Rajan Sharma; Neena Gupta; Rinku Ahuja; Manu Jaggi; Anu T. Singh; Rama Mukherjee


Book ID
106452062
Publisher
Springer Netherlands
Year
2006
Tongue
English
Weight
344 KB
Volume
12
Category
Article
ISSN
1573-3149

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Substance P analogs containing α,α-dialk
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## Abstract Six analogs (peptides **1–6**) of the potent substance P (SP) derivative known as ‘Antagonist D’ were synthesized by substituting constrained amino acids Aib or Acp (cycloleucine, 1‐amino cyclopentane carboxylic acid) at different positions in the Antagonist D sequence: D‐Arg^1^‐Pro^2^‐

Bombesin analogs containing α-amino-isob
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## Abstract Six octapeptide bombesin (BN) analogs were synthesized by substituting α‐aminoisobutyric acid (Aib), in place of Ala^9^ or Gly^11^, or both, in the [D‐Phe^6^, __des__Met^14^]‐BN (6–14) sequence: D‐Phe^6^‐Gln^7^‐Trp^8^‐Ala^9^‐Val^10^‐Gly^11^‐His^12^‐Leu^13^‐NH~2~ (**P0**). Additionally,