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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

โœ Scribed by Ludwig Kappos; David Li; Peter A Calabresi; Paul O'Connor; Amit Bar-Or; Frederik Barkhof; Ming Yin; David Leppert; Robert Glanzman; Jeroen Tinbergen; Stephen L Hauser


Book ID
117309415
Publisher
The Lancet
Year
2011
Tongue
English
Weight
337 KB
Volume
378
Category
Article
ISSN
0140-6736

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Ocrelizumab in relapsing-remitting multi
โœ Ludwig Kappos; David Li; Peter A Calabresi; Paul O'Connor; Amit Bar-Or; Frederik ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› The Lancet ๐ŸŒ English โš– 337 KB

## Background: B lymphocytes are implicated in the pathogenesis of multiple sclerosis. we aimed to assess efficacy and safety of two dose regimens of the humanised anti-cd20 monoclonal antibody ocrelizumab in patients with relapsing-remitting multiple sclerosis. ## Methods: We did a multicentre,