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Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats

โœ Scribed by M. A. Abdel-Wahhab; S. A. Nada; M. S. Arbid

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
631 KB
Volume
19
Category
Article
ISSN
0260-437X

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โœฆ Synopsis

l-Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l-methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue.

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