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Occurrence of the 15-hydroxy derivative of dihomogammalinolenic acid in human platelets and its biological effect

✍ Scribed by M. Guichardant; S. Naltachayan-Durbin; M. Lagarde

Book ID
115739962
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
527 KB
Volume
962
Category
Article
ISSN
0005-2760

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✍ L. Iversen; K. Fogh; K. Kragballe πŸ“‚ Article πŸ“… 1992 πŸ› Springer-Verlag 🌐 English βš– 478 KB

The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (