Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions

Ideal enantiomeric resolution (Preferent

Ideal enantiomeric resolution (Preferential Enrichment) by recrystallization of a racemic compound. V: Relationship between Preferential Enrichment and crystal structures

✍ Hiroki Takahashi; Rui Tamura; Takanori Ushio; Yoshitaka Nakajima; Ken Hirotsu 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

The X-ray crystal structure of (±)- [2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylammonium p-nitrobenzenesulfonate [(±)-NNMe 2 ], which shows the novel enantiomeric resolution phenomenon Preferential Enrichment, has been compared with that of (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy) ph