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Occurrence of male phenotype in genotypic females with congenital virilizing adrenal hyperplasia

โœ Scribed by Chan-Cua, Sioksoan ;Freidenberg, Gary ;Jones, Kenneth Lee


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
700 KB
Volume
34
Category
Article
ISSN
0148-7299

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The steroid 21-hydroxylase enzyme (P450c21) is a member of the cytochrome P450 gene superfamily and is essential in the synthesis of cortisol and aldosterone. Defects in the P450c21B gene cause congenital adrenal hyperplasia (CAH), a common genetic disorder leading to virilization of newborn females