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Occurrence of antibodies TO L1, L2, E4 and E7 gene products of human papillomavirus types 6b, 16 and 18 among cervical cancer patients and controls

✍ Scribed by Heinrich G. Köchel; Masyar Monazahian; Kai Sievert; Michaela Höhne; Christoph Thomssen; Alexander Teichmann; Peter Arendt; Reiner Thomssen

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
820 KB
Volume
48
Category
Article
ISSN
0020-7136

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✦ Synopsis

Sera from I 18 women of 33 to over 90 years of age, with or without a history of cervical squamous-cell carcinoma, were examined for the presence of antibodies to HPV-6b, HPV-I6 and HPV-18 LI, U, E4, and E7 gene products by the use of bacterially derived P-Gal fusion proteins and Western-blot analysis. Among the cervical cancer patients, 29/46 (63.0%) were positive for antibodies to E4 and/or E7 of HPV-I 6 and/or E7 of HPV-18. In contrast, only 2 of 31 (6.5%) non-genital cancer patients and 4 of 41 (9.8%) healthy individuals were antibody-positive for HPV-I6 E4 or E7. while antibodies to the homologous proteins of HPV-18 could not be detected. Prevalence rates of antibodies to the HPV-1611 8 late proteins were 25/46 (54.3%) in the cervical carcinoma group, 1313 I (4 I .9%) among women with non-genital cancer types, and 18/41 (43.9%) 4To whom correspondence and reprint requests should be sent.

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