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Occurrence of ankylosing spondylitis and multiple sclerosis-like syndrome in a HLA-B27 positive patient

โœ Scribed by Andrea Mignarri; Maria Teresa Dotti; Carla Battisti; Ignazio Vallone; Antonio Federico

Publisher
Springer Milan
Year
2009
Tongue
English
Weight
210 KB
Volume
30
Category
Article
ISSN
1590-1874

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A comparative study of HLA genes in HLAโ€“B27 positive ankylosing spondylitis and HLAโ€“B27 positive peripheral reactive arthritis
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## Objective: To determine whether hla-b27 positive patients with ankylosing spondylitis (as) and reactive arthritis (rea) share additional hla factors that confer disease susceptibility. ## Methods: Hla class i antigens were typed serologically, and class ii antigens molecularly, in samples take

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## Abstract The present study was performed on 61 HLAโ€B27 positive firstโ€degree relatives and 40 HLAโ€B27 negative relatives of 20 HLAโ€B27 positive probands with ankylosing spondylitis (AS). Of 24 HLAโ€B27 positive relatives 45 years or older, 21% had AS and 38% sacroiliitis. The HLAโ€B27 negative rel