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Occurrence of a regulatory deficiency in purine biosynthesis among purA mutants of Salmonella typhimurium

✍ Scribed by Benson, Charles E. ;Gots, Joseph S.

Publisher
Springer
Year
1976
Tongue
English
Weight
598 KB
Volume
145
Category
Article
ISSN
0026-8925

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✦ Synopsis

A defect in the repression of the de novo purine biosynthetic enzymes was detected among purA mutants of Salmonella typhimurium. We suggest that the defect is caused by an altered purine regulation gene (purR) which affects the response level of at least five of the de novo enzymes to repression by excess adenine. Thus the unlinked genes controlling these enzymes constitute a regulation controlled wholly or in part by a purR gene product. The regulation of the guanine operon is regulated by some other mechanism independent of purR.

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