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Occurrence, conformational features and amino acid propensities for the -helix

โœ Scribed by Fodje, M.N.; Al-Karadaghi, S.


Book ID
118116251
Publisher
Oxford University Press
Year
2002
Tongue
English
Weight
266 KB
Volume
15
Category
Article
ISSN
1741-0126

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All four optically pure isomers of the highly conformationally constrained novel chimeric amino acid, ~-isopropylphenylalanine or ~-phenylleucine, were asymmetrically synthesized in five to six steps in 20 -25% overall yield. Computer-assisted molecular modeling revealed that the ~-isopropyl group i