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Occurrence and specificity of IgE antibodies to isocyanates in occupationally exposed workers

✍ Scribed by S. Cvitanović; Lj. Zekan; M. Marušić

Book ID
104750105
Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
396 KB
Volume
61
Category
Article
ISSN
0340-0131

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✦ Synopsis

The levels of Ig E antibodies specific for toluene-diisocyanate (TDI), diphenylmethane-diisocyanate (MDI) and hexamethylene-diisocyanate (HDI) were determined in eight workers with an unequivocal history of professional asthma, all having been exposed to isocyanates in the working atmosphere Five workers were examined at the clinical onset of asthma. They had serum Ig E antibodies specific for TDI, MDI and HDI, and depressed pulmonary ventilation parameters In contrast, three workers, who had only a mild bronchial obstruction at the time of testing, had no anti-isocyanate Ig E antibodies The results indicated that asthma was induced by type I allergic reaction, but other pathogenetic mechanisms of bronchoobstruction could not be completely ruled out.

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