Occupational health survey on workers exposed to 2-bromopropane at low concentrations

✍ Scribed by Gaku Ichihara; Xuncheng Ding; Xiaozhong Yu; Xiangdong Wu; Michihiro Kamijima; Simeng Peng; Xuezhi Jiang; Yasuhiro Takeuchi

• Book ID: 101240097
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 82 KB
• Volume: 35
• Category: Article
• ISSN: 0271-3586
• DOI: 10.1002/(sici)1097-0274(199905)35:5<523::aid-ajim10>3.0.co;2-w

✦ Synopsis

Background:

Recent case studies in korea and animal studies revealed the reproductive and hematopoietic toxicity of 2-bromopropane introduced into workplaces as an alternative to ozone-layer depleting chlorofluorocarbons. we aimed to clarify the dose-effect relationship of 2-bromopropane in workers.

Method:

The exposure concentration of 2-bromopropane and hematological indices, hormonal levels, menstruation status, and sperm indices were examined in 25 workers (11 males, 14 females) at a 2-bromopropane factory. regression analyses of the examined indices against time-weighted average (twa) of exposure concentration were conducted.

Results:

Amenorrhea or polymenorrhea was observed only in older females. hematological indices had a significant relation with twa of exposure concentration in females with normal menstruation. however, no other indices showed any significant relation with twa of 2-bromopropane.

Conclusions:

No severe cases of reproductive or hematopoietic disorders were found at less than 10 ppm (twa), but a possible adverse effect of 2-bromopropane on hematopoiesis could not be disproved.