Occult sporadic medullary microcarcinoma with lymph node metastases

✍ Scribed by Maria Sironi; Luigi Cozzi; Roberto Pareschi; Gian Luigi Spreafico; Agnese Assi

• Book ID: 101244305
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 321 KB
• Volume: 21
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/(sici)1097-0339(199909)21:3<203::aid-dc12>3.0.co;2-t

✦ Synopsis

A sporadic form of medullary occult microcarcinoma was cytologically diagnosed, by fine-needle aspiration biopsy (FNAB), on metastatic cervical lymph nodes. The cytologic specimens were partially smeared and partially zinc-formalin-fixed, so that a microinclusion clot for immunohistochemical studies would be possible. The reactivity to calcitonin of neoplastic cells obtained from metastatic cervical lymph nodes supported the search for a thyroid tumor, which only a careful echographic study revealed.

Under sonographic guidance, FNAB on a 0.5-cm hypoechoid nodule was performed. The smears were diagnostic of medullary carcinoma. A total thyroidectomy with node dissection was made.