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Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat

โœ Scribed by Norio Takahashi; Homare Shiomi; Nobuhiro Kushida; Fei Liu; Kei Ishibashi; Tomohiko Yanagida; Keiichi Shishido; Ken Aikawa; Osamu Yamaguchi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
168 KB
Volume
28
Category
Article
ISSN
0733-2467

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## Abstract ## Aims To investigate the concentration and activity of RhoA in detrusor and urothelium, as well as the effects of a Rhoโ€kinase inhibitor, Yโ€27632 {(+)โ€(R)โ€transโ€4โ€(1โ€aminoethyl)โ€Nโ€(4โ€pyridyl) cyclohexanecarboxamide dihydrochloride}, on contraction of the pig urinary bladder. ## Meth