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Observations upon the Metabolism of Fluorocitrate in Rats

✍ Scribed by Rudolph Peters, M. Shorthouse, P. F. V. Ward and E. M. McDowell

Book ID
123660468
Publisher
The Royal Society
Year
1972
Tongue
English
Weight
983 KB
Volume
182
Category
Article
ISSN
0080-4649

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Fluoroacetate and its toxic metabolite fluorocitrate cause inhibition of aconitase. In brain tissue, both substances are preferentially taken up by glial cells and leads to inhibition of the glial TCA cycle. It is important to realise, however, that the glia-specificity of these compounds depends bo