𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Observations on the vilsmeier reaction part 1

✍ Scribed by Andrew P. Shawcross; Stephen P. Stanforth

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
606 KB
Volume
44
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

Rre reaction of N~~i~tit~t~~~yl~i~~~ derivatives under Vilsmeie~&ditions afforded proikt~ derived from an intramlecular hydride shift when one ,N=substituent was benzyl or 4-chlurobenzyf. introduction of a forz@l group into electron-rich arcmtic systems. W have investigated the Vilsmeier reaction of N,N_dis~tituted_6~~iline derivatives tltf-(3) and, for ccqmrison, &N_dSsubstitu;ed aniline derivatives (4) and (S), Preparatia of ccarpcKprds (l)-f5) N,~~(2~~yl)-4-~thylaniline fl) was prepared by cYano&hylation of -_I 4-mthylaniline4. CXqomds ~2bW were all prepared by a simi.lar qanoethylation pmcedue. plus, _Wyl-4inethyUniline afforded !!!-~~~f2~ Yl)-e-=thylaniline ((2) (46% yield), 1461

📜 SIMILAR VOLUMES

Studies on the Vilsmeier-haack reaction.
Studies on the Vilsmeier-haack reaction. Part XIII: Novel heterocyclo-substituted 4,4′-bi-pyrazolyl dithiocarbamate derivatives
✍ Ibrahim M. A. Awad 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 469 KB

## Abstract 5‐Imino‐3‐methyl‐l‐phenyl‐2‐pyrazoline‐4‐dithiocarbamic acid (I) underwent simultaneous formylation and dimerization reactions with the Vilsmeier reagent giving 4‐[5′‐imino‐3‐(1″‐formyl‐2″‐dimethylaminoethenyl)‐3′‐methyl‐1′‐phenyl‐1′H‐pyrazolo‐4′‐dithiocarbamyl‐2,4‐dihydro‐3‐imino‐5‐met