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Observations on the differential metabolism and biological activity of the optical isomers of cyclophosphamide

โœ Scribed by P.J. Cox; P.B. Farmer; M. Jarman; M. Jones; W.J. Stec; R. Kinas


Book ID
115773137
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
177 KB
Volume
25
Category
Article
ISSN
0006-2952

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The metabolism of cyclophosphamide-44, (2-[bis(2-chloroethyI)amino]-tetrahydro-4,4-dideuterio-2H-1,3,2-oxazaphosphorine 2-oxide), was studied. The first detectable metabolite was a hydroxy derivative which was trapped with ethanol. Mass spectrometry of the resulting two ethowy derivatives and of the