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Observation of a Secondary Tritium Isotope Effect in the Chorismate Synthase Reaction

✍ Scribed by Balasubramanian, Shankar; Coggins, John R.; Abell, Chris


Book ID
126437011
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
1002 KB
Volume
34
Category
Article
ISSN
0006-2960

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Chorismate synthase (EC 4.6.1.4) is the shikimate pathway enzyme that catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to chorismate. The enzyme reaction is unusual because it involves a trans-1,4 elimination of the C-3 phosphate and the C-6 proR hydrogen and it has an absolute