𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Obesity and liver cancer: A key role for interleukin-6 and signal transducer and activator of transcription 3?

✍ Scribed by Christoph Roderburg; Christian Trautwein

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
221 KB
Volume
51
Category
Article
ISSN
0270-9139

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✦ Synopsis

Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carcinoma (HCC), the common form of liver cancer whose occurrence and progression are the most strongly affected by obesity among all cancers. We now demonstrate that either dietary or genetic obesity is a potent bona fide liver tumor promoter in mice. Obesity-promoted HCC development was dependent on enhanced production of the tumorpromoting cytokines IL-6 and TNF, which cause hepatic inflammation and activation of the oncogenic transcription factor STAT3. The chronic inflammatory response caused by obesity and enhanced production of IL-6 and TNF may also increase the risk of other cancers.

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