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OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human

✍ Scribed by Sun, Pengyuan; Wang, Changyuan; Liu, Qi; Meng, Qiang; Zhang, Aijie; Huo, Xiaokui; Sun, Huijun; Liu, Kexin

Book ID
122354350
Publisher
Elsevier
Year
2014
Tongue
English
Weight
346 KB
Volume
66
Category
Article
ISSN
1734-1140

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Hepatic metabolism and biliary excretion
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The study was designed to investigate the hepatic metabolism and transport system of valerenic acid, a main active constituent of valerian, in isolated perfused livers from Wistar and Mrp2-deficient TR(-) rats. After administration of 20 microM valerenic acid, the formation of seven valerenic acid g