The tyrosine kinase inhibitor dasatinib
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Kate Vandyke; Andrea L Dewar; Peter Diamond; Stephen Fitter; Christopher G Schul
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Article
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2010
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American Society for Bone and Mineral Research
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English
β 423 KB
## Abstract Dasatinib is a potent tyrosine kinase inhibitor that is used to treat chronic myeloid leukemia in patients resistant or intolerant to imatinib mesylate. While designed to inhibit Abl and Src kinases, dasatinib shows multitarget effects, including inhibition of the macrophage colonyβstim