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O6-Methylguanine-DNA Methyltransferase Leu84Phe and Ile143Val Polymorphisms and Risk of Colorectal Cancer in the Nurses’ Health Study and Physicians’ Health Study (United States)

✍ Scribed by Gregory J. Tranah; James Bugni; Edward Giovannucci; Jing Ma; Charles Fuchs; Lisa Hines; Leona Samson; David J. Hunter

Publisher
Springer Netherlands
Year
2006
Tongue
English
Weight
245 KB
Volume
17
Category
Article
ISSN
0957-5243

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✍ Gregory J. Tranah; Andrew T. Chan; Edward Giovannucci; Jing Ma; Charles Fuchs; D 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Two coding‐region __mEH__ variants (Tyr113His, His139Arg) and __CYP2C9__ variants (Arg144Cys, I