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O6-Methylguanine-DNA methyltransferase activity and induction of novel immunogenicity in murine tumor cells treated with methylating agents

✍ Scribed by Roberta Bianchi; Lorenzo Citti; Rita Beghetti; Luigina Romani; Maurizio D'Incalci; Paolo Puccetti; Maria Cristina Fioretti


Publisher
Springer
Year
1992
Tongue
English
Weight
690 KB
Volume
29
Category
Article
ISSN
0344-5704

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## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^‐methylguanine‐DNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu