Methylation of the O6-methylguanine-DNA
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Rana Abdel-Fattah; Adam Glick; Ishtiaq Rehman; Patrick Maiberger; Henry Hennings
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Article
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2005
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John Wiley and Sons
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French
β 212 KB
## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^βmethylguanineβDNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu