O51 Acute myeloid leukemia in the Czech Republic and the Slovak Republic from 1996 to 2007. Prognostic and therapeutic results of 1890 patients from the ALERT registry
✍ Scribed by T. Szotkowski; J. Voglová; V. Koza; T. Kozák; M. Doubek; J. Maaloufova; P. Kotouček; L. Demetrovičová; E. Tóthová; L. Chudej; J. Mayer; P. Žák; P. Cetkovský; K. Michalová; M. Jarošová; E. Demečková; J. Mužík; L. Dušek; K. Indrák
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 48 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
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✦ Synopsis
Objectives: To study the spectrum of pathogens isolated in patients with neutropenia and positive blood cultures between January 2005 and December 2006. Methods: A total of 161 positive blood culture findings were enrolled in this study. Blood cultures were collected during febrile episodes in patients with hematological malignancies (AML, ALL, MM) and severe aplastic anemia. Results: The most frequent isolated pathogens in this study were Gram-positive bacteria with the predominance of methicillin-resistant coagulase negative staphylococci CoNS (42.7%). Among other Gram-positive cultures Enterococcus faecalis and E. fecium 8.7%, Corynebacterium spp. 3%, S. aureus 2.5%, Streptococci 4.3%, methicillin-susceptible CoNS 6%, were isolated. The most common Gram-negative agents were E. coli 7.5% and Kl. pneumoniae + Kl. oxytoca 5%. Among patients with invasive fungal infections the predominant agent was Candida albicans (5%). C. albicans isolated in two patients was resistant to fluconazol and voriconazol. Conclusions: In neutropenic patients with bacteremia, the predominant pathogens were methicillin-resistant coagulase negative staphylococci. Isolation of C. albicans resistant to fluconazol and voriconazol is an unusual finding.
O51 Acute myeloid leukemia in the Czech Republic and the Slovak Republic from 1996 to 2007. Prognostic and therapeutic results of 1890 patients from the ALERT registry