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O43 - Allele-specific transcriptional regulation of HLA-DQB1 genes

✍ Scribed by Gerald T. Nepom; Teresa Sukiennicki; Jon S. Beaty


Book ID
116114450
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
154 KB
Volume
47
Category
Article
ISSN
0198-8859

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The beta chain of the HLA-DQ molecule is shorter by eight amino acid residues than other major histocompatibility complex class II beta chains due to elimination of the fifth exon coding for part of the cytoplasmic domain. This elimination is caused by one base substitution in the splice acceptor si