O32 Skin iron concentration, a simple, highly sensitive method for iron stores in thalassemia patients
✍ Scribed by A. El-Beshlawy; I. Youssry; N.A. Mohsen; O.G. Shaker; A. El-Hennawy; R. Fawzy; N.M. Abu-Zeid
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 56 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
No coin nor oath required. For personal study only.
✦ Synopsis
Results: Failure of puberty was present in 80% of boys and 75% of girls aged 12 22 years. Gonadotropin insufficiency was found in most of the patients with lack of puberty. Arrested puberty was noted in five boys (25%) and six girls (30%). Ten girls (50%) did not menstruate, two (10%) had oligomenorrhea, one (5%) had irregular menstrual cycles, and two (10%) developed secondary amenorrhea. Using univariate analyses and stepwise logistic regression analysis after adjustment for confounding factors, serum ferritin at the time of the study was identified as an independent risk factor for hypogonadotropic hypogonadism, with an odds ratio of 28.40 (95% confidence interval 3.25 245.15), P = 0.003 with a B value of 3.24 (standard error, 1.12). Conclusions: We conclude that failure of puberty is very common in our thalassemic patients, which necessitates newer protocols of treatment, correct blood transfusion and chelation therapy.