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o-Phthalaldehyde Activates the Ca2+ Release Mechanism from Skeletal Muscle Sarcoplasmic Reticulum

โœ Scribed by Jonathan J. Abramson; Shawn P. Mullen; Steffen Koehler; David Mansoor; Peter Anderson; Carl C. Wamser; Trudy J. Swan; Terence G. Favero

Book ID
115568802
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
208 KB
Volume
391
Category
Article
ISSN
0003-9861

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Ca2+ release from skeletal sarcoplasmic reticulum (SR) could be regulated by at least three mechanisms: 1) Ca2+, 2) calmodulin, and 3) Ca2+/calmodulin-dependent phosphorylation. Bell-shaped Ca(2+)-dependence of Ca2+ release from both actively- and passively-loaded SR vesicles suggest that opening an