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O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants

✍ Scribed by Steven M Fogelman; Jürgen Schmider; Karthik Venkatakrishnan; Lisa L von Moltke; Jerold S Harmatz; Richard I Shader; David J Greenblatt


Book ID
114282311
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
260 KB
Volume
20
Category
Article
ISSN
1470-634X

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✍ Wolfgang Schüler; P. Schmieder; Horst Kessler; Uwe Christians; Ines Holze; Karl- 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 775 KB

FK506 is currently under investigation as immunosuppressant after organ transplantation and in immune diseases. The structure of a demethylated metabolite 1 of FK506 isolated after in oitro metabolism by human-liver microsomes was established using two-dimensional homo-and heteronuclear NMR experime