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O-56 High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1 and ERK-1/2 is associated with development of tamoxifen resistance in ER positive breast cancer patients

✍ Scribed by Carol Watson; Jaclyn S. Long; Clare Orange; Claire L. Tannahill; Elizabeth Mallon; Liane M. McGlynn; Susan Pyne; Nigel J. Pyne; Joanne Edwards


Book ID
119233767
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
32 KB
Volume
8
Category
Article
ISSN
1359-6349

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐