O-45 Reproducibility and interpretation of quantitative gene expression measurements in breast cancer biopsies
β Scribed by A. Larionov; E. Murray; W.R. Miller; J.M. Dixon
- Book ID
- 118626001
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 45 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1359-6349
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A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcoholformalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC).
## Abstract Tumor choline metabolites have potential for use as diagnostic indicators of breast cancer phenotype and can be nonβinvasively monitored __in vivo__ by MRS. Extract studies have determined that the principle diagnostic component of these peaks is phosphocholine (PCho), the biosynthetic