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O-2′,3′-Ketal-Nucleolipids of the Cytostatic 5-Fluorouridine: Synthesis, Lipophilicity, and Acidic Stability

✍ Scribed by Edith Malecki; Helmut Rosemeyer

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 303 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201000121

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✦ Synopsis

Abstract

The synthesis of a series of cyclic and acyclic O‐2′,3′‐ketal derivatives of the cancerostatic 5‐fluorouridine (2a) is described. The novel compounds were characterized by ^1^H‐ and ^13^C‐NMR, and UV spectroscopy, as well as by elemental analyses. The lipophilicity values (log P, retention times in RP‐18 HPLC) of the cyclic ketals were determined and related to the ring tensions as well as the acid stability of the spiro‐linked ketal rings.

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