Nutritional factors in a mouse model of Rett syndrome
β Scribed by Nupur Nag; Bonnie Ward; Joanne E. Berger-Sweeney
- Book ID
- 108218820
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 276 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0149-7634
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Rett syndrome (RTT) is caused by mutations in the Xβlinked gene __MECP2__. While patients with RTT show widespread changes in brain function, relatively few studies document changes in brain structure and none examine in detail whether mutations causing more severe clinical phenotypes a
Thirty-five percent of patients with Rett syndrome carry nonsense mutations in the __MECP2__ gene. We have recently shown in transfected HeLa cells that readthrough of nonsense mutations in the __MECP2__ gene can be achieved by treatment with gentamicin and geneticin. This study was performed to tes