Molecular studies have revealed that microsatellite instability and loss of heterozygosity occurred in head-and-neck cancer, suggesting the involvement both of suppressor and of mutator pathways in head-and-neck carcinogenesis. There is evidence for relations between tumor phenotype and clinical par
Nutritional factors as predictors of response to radio-chemotherapy and survival in unresectable squamous head and neck carcinoma
✍ Scribed by Sébastien Salas; Jean-Laurent Deville; Roch Giorgi; Thierry Pignon; Danielle Bagarry; Karine Barrau; Michel Zanaret; Antoine Giovanni; Aude Bourgeois; Roger Favre; Florence Duffaud
- Book ID
- 118497124
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 88 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0167-8140
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The high tumor response rates associated with intensive chemotherapy in previously untreated patients with advanced head and neck squamous cell carcinoma (HNSCC) led to the initiation of a multi-institutional National Cancer Institute trial. This trial used preoperative chemotherapy in patients with
## Abstract ## BACKGROUND The goal of the current study was to evaluate the efficacy and toxicity of paclitaxel, cisplatin (P), tegafur (T), and leucovorin (L) as a neoadjuvant chemotherapy (CT) for patients with advanced, unresectable squamous cell carcinoma of the head and neck. ## METHODS Fro