Numerical study of mass transfer coefficient in a 3D flat-plate rectangular microchannel bioreactor

✍ Scribed by Yan Zeng; Thong-See Lee; Peng Yu; Hong-Tong Low

• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 368 KB
• Volume: 34
• Category: Article
• ISSN: 0735-1933
• DOI: 10.1016/j.icheatmasstransfer.2006.11.007

✦ Synopsis

Microchannel bioreactors have been used in many studies to investigate the fluid microenvironment around cells. In the present study, a three-dimensional numerical model was developed to simulate the fluid flow and mass transfer in a 3D flat-plate rectangular microchannel bioreactor with a monolayer of cells adherent to the bottom. The numerical results of mass transfer were well correlated in terms of two dimensionless parameters: Sherwood number at base (Sh) and effective distance (κ). The generalized results show the mass transfer characteristic in the flat-plate microchannel bioreactors, which may find applications in culturing cells in these bioreactors.