✦ LIBER ✦

Numerical characterization of the conformation of cyclic peptides and its application

✍ Scribed by Xiaoqing Liu; Zhilong Xiu; Xiaohui Li

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 185 KB
Volume: 28
Category: Article
ISSN: 0192-8651
DOI: 10.1002/jcc.20744

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Many classes of functional cyclic peptide molecules are determined by experimental techniques, but few similarities of cyclic peptides are detectable. We propose three numerical characterizations of conformations of cyclic peptides. By incorporating the information on atomic coordinates of cyclic peptides, the coordinates are transformed into a characteristic sequence. Then we calculate its center of gravity, the eigenvalues of its Euclidean and L/L matrices, and regard them as descriptors to numerically characterize the conformations of cyclic peptides. Finally, the method is tested by analyzing the similarities of cyclic peptides presented in Table 1. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007

📜 SIMILAR VOLUMES

Photomodulation of the Conformation of C

Photomodulation of the Conformation of Cyclic Peptides with Azobenzene Moieties in the Peptide Backbone

✍ Raymond Behrendt; Christian Renner; Michaela Schenk; Fengqi Wang; Josef Wachtvei 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

ChemInform Abstract: Cyclic Peptides fro

ChemInform Abstract: Cyclic Peptides from Higher Plants. Part 35. Conformation of Cyclic Heptapeptides: Solid and Solution State Conformation of Yunnanin A.

✍ H. MORITA; T. KAYASHITA; K. TAKEYA; H. ITOKAWA; M. SHIRO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

Conformational Preference and Potential

Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides

✍ Jayanta Chatterjee; Dale F. Mierke; Horst Kessler 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

## Abstract Systematic __N__‐methylation of all peptide bonds in the cyclic pentapeptide cyclo(‐D‐Ala‐Ala~4~‐) has been performed yielding 30 different __N__‐methylated derivatives, of which only seven displayed a single conformation on the NMR time scale. The conformation of these differentially _

Application of the distance geometry alg

Application of the distance geometry algorithm to cyclic oligopeptide conformation searches

✍ Catherine E. Peishoff; J. Scott Dixon; Kenneth D. Kopple 📂 Article 📅 1990 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 870 KB

The distance geometry algorithm as embodied in the program DGEOM was examined as a method for searching cyclic peptide conformations. Conformations were randomly generated using covalent distance and chirality constraints, but torsion angle rather than distance sampling was used for 1,4 relationship

ChemInform Abstract: Application of the

ChemInform Abstract: Application of the Peptide Claisen Rearrangement Toward the Synthesis of Cyclic Peptides.

✍ Uli Kazmaier; Sabine Maier 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

Studies on cyclic peptides. III. The spe

Studies on cyclic peptides. III. The specific interaction of cyclic peptides with benzene and an application of the solvent-induced nmr shift to the conformational analysis of cyclo-(Pro-Sar-Gly)2

✍ Toshiharu Sugihara; Yukio Imanishi; Toshinobu Higashimura 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 661 KB

The interaction between cyclic peptides [cyclo-(Sara), cyclo-(Pro-Sar-Gly)r, cyclo-(Sar-Sar), and cyclo-(Sar-Gly)] with benzene has been investigated by nmr spectroscopy. The experiment with cyclo-(Sarr) showed that benzene int,eracted preferentially with the frans peptide bond in a similar manner t