Numerical and experimental study of a novel phase contrast magnetic resonance (PC-MR) imaging technique: Sparse interleaved referencing PC-MR imaging
✍ Scribed by Longchuan Li; Mark Doyle; Geetha Rayarao; Robert W.W. Biederman; Andreas Anayiotos
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 928 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To use numerical simulation and experimental approaches to introduce a novel phase contrast magnetic resonance (PC‐MR) data processing technique termed Sparse Interleaved Referencing PC‐MR, with potential to improve accuracy, temporal resolution, and signal‐to‐noise ratio (SNR) of PC‐MR data.
Materials and Methods
Computational fluid dynamics data were generated for a two‐chamber orifice flow model simulating valvular regurgitation. The numerical results were validated and used to simulate conventional and Sparse Interleaved Referencing PC‐MR data acquisitions. Common data sets were processed using conventional and Sparse Interleaved Referencing approaches and quantitative errors in velocity‐time waveforms were measured and compared. In vitro phantom jet flow data and in vivo ascending aorta data were acquired and used to simulate Sparse Interleaved Referencing PC‐MR.
Results
The Sparse Interleaved Referencing PC‐MR data showed significantly better representation of the velocity‐time waveform in three areas: (i) lower root‐mean‐square errors (9.0 ± 1.0% versus 24.0 ± 0.2%; P < 0.005), (ii) simulation of conventionally processed data showed a pattern of peak velocity overestimation, which was experimentally demonstrated in in vitro data, whereas overestimation of peak velocity was dramatically attenuated using Sparse Interleaved Referencing (2.8 ± 0.4% versus 16.9 ± 6.4%, P < 0.005), and (iii) compared with the conventional scan, an average of 119.4 ± 26.6% (P < 0.005) SNR was realized in in vitro and in vivo Sparse Interleaved Referencing PC‐MR data.
Conclusion
Simulation and in vitro/in vivo results show that Sparse Interleaved Referencing PC‐MR processed data in pulsatile and jet flow showed higher accuracy, better peak velocity representation, and improved SNR compared with the data processed using the conventional PC‐MR method. J. Magn. Reson. Imaging 2008;27:898–907. © 2008 Wiley‐Liss, Inc.