Numbering of cloned P2 purinoceptors

✍ Scribed by Geoffrey Burnstock; Brian F. King

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 513 KB
• Volume: 38
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199605)38:1<67::aid-ddr9>3.0.co;2-j

✦ Synopsis

Over the last 3 years (March, 1993 to June, 19961, DNA sequences have been isolated for some 40 proteins that act as P2 purinoceptors. This explosion in receptor subtypes for nucleotide signalling and rate of advance (1 new receptor per month) have caused problems with the classification of these recombinant purinoceptors. At the request of the research community in this field, a "Purinoceptor Update Newsheet" was compiled at University College London with the view to monitoring and opening for general discussion new findngs on P2 purinoceptor cloning and rapidly disseminating this information to investigators in this field. The present paper explains the system of numbering of the two families of receptor subtypes as proposed by Abbracchio and Burnstock I(1994): Pharmacol Ther 64:445-4751 1P2X1. , and P2Y1-, purinoceptors, as extended families of ligand-gated and G protein-coupled receptors), and the order in which these subtypes appear in "Newsheet" tables.