Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population
✍ Scribed by Novin Balafkan; Charalampos Tzoulis; Bernd Müller; Kristoffer Haugarvoll; Ole-Bjørn Tysnes; Jan Petter Larsen; Laurence A. Bindoff
- Book ID
- 119327075
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 221 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1567-7249
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In several neurodegenerative diseases, anticipation or increase in disease severity in succeeding generations within families correlates with expansions of an intragenic CAG/CTG repeat sequence above the normal range through the generations of a pedigree. Some kindreds of familial Parkinson's diseas
## Abstract Huntington's disease (HD) is caused by the expansion of the number of CAG repeats on the chromosome 4p16.3, which results in elongated glutamine tract of huntingtin. The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effe