Number and sex of offspring of ΔF508 carriers outside cystic fibrosis families
✍ Scribed by H. G. de Vries; J. M. Collée; W. P. Meeuwsen; H. Scheffer; L. P. Ten Kate
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 94 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Preimplantation genetic diagnosis (PGD) was attempted in 12 couples in whom both parents carry the common AF508 deletion causing cystic fibrosis (CF). In vitro fertilization (IVF) was followed by cleavage stage biopsy on days 2 and 3 and removal of one or two cells for genetic analysis by nested pol
In the present paper, we applied surface plasmon resonance (SPR) and biosensor technologies for biospecific interaction analysis (BIA) to detect DF508 mutation (F508del) of the cystic fibrosis transmembrane regulator (CFTR) gene in both homozygous as well as heterozygous human subjects. The proposed
Cystic fibrosis (CF) is an autosomal recessive disorder which is considered to be the most frequent genetic disorder in the Caucasian population. In a large number of populations tested it is found in an average frequency of 1 CF chromosome per 25 individuals, resulting in a patient frequency of 1:2