𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Number and affinity of insulin receptors in intact human subjects

✍ Scribed by R. H. Jones; P. H. Sönksen; M. A. Boroujerdi; E. R. Carson

Book ID
104697239
Publisher
Springer
Year
1984
Tongue
English
Weight
533 KB
Volume
27
Category
Article
ISSN
0012-186X

No coin nor oath required. For personal study only.

✦ Synopsis

A simple model of the distribution and metabolism of insulin in vivo has been evaluated using data from insulin infusion into a group of normal subjects. The major rate-limiting step for access to degradation pathways is assumed to consist of binding of the ligand to a single population of insulin receptor sites, except that provision is made for the possibility of linear non-receptor-mediated degradation and for the phenomenon of negative cooperativity. The model has been shown to accommodate the non-linearity of insulin metabolism, allows, evaluation of receptor association and dissociation constants and provides for the first time an estimate of total accessible receptor number in the intact organism. For normal fasting man the model predicts 1.00 +/- 0.05 nmol accessible binding sites/kg (mean +/- SD).

📜 SIMILAR VOLUMES

Insulin receptors are widely distributed
Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity
✍ Hopkins, D.F.C.; Williams, G. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 2 views

Insulin receptors differing structurally from those in other tissues have been demonstrated in brain from many species. Subtle differences in binding properties have been reported between insulin receptors in brain and other tissues, including differences in affinity of pig brain receptors for human