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Nucleotides. Part XLVIII. Synthesis of 2′-amino-2′-deoxyarabinonucleoside phosphoramidite building blocks

✍ Scribed by Gunter Walcher; Wolfgang Pfleiderer

Book ID
102860968
Publisher
John Wiley and Sons
Year
1996
Tongue
German
Weight
580 KB
Volume
79
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Chemical syntheses of 2′‐amino‐2′‐deoxyarabinonucleosides of uracil, thymine, cytosine, adenine, and guanine and their conversion into suitably protected 3′‐phosphoramidite building blocks 24–28 for oligonucleotide synthesis are described. The 2‐(4‐nitrophenyl)ethoxycarbonyl (npeoc) group was used for protection of the aglycon and the 2′‐amino functions.

📜 SIMILAR VOLUMES

Nucleotides, Part LXV , Synthesis of 2′-
Nucleotides, Part LXV , Synthesis of 2′-Deoxyribonucleoside 5′-Phosphoramidites: New Building Blocks for the Inverse (5′-3′)-Oligonucleotide Approach
✍ Thomas Wagner; Wolfgang Pfleiderer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 266 KB 👁 1 views

With best personal wishes dedicated to Prof. Dr. Albert Eschenmoser on the occassion of his 75th birthday The syntheses of the 3'-O-(4,4'-dimethoxytrityl)-protected 5'-phosphoramidites 25 ± 28 and 5'-(hydrogen succinates) 29 ± 32, which can be used as monomeric building blocks for the inverse (5'-3'