𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nucleotides. Part XLI. The 2-dansylethoxycarbonyl ( 2-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}ethoxycarbonyl; dnseoc) group for protection of the 5′-hydroxy function in oligodeoxyribonucleotide synthesis

✍ Scribed by Frank Bergmann; Wolfgang Pfleiderer

Publisher
John Wiley and Sons
Year
1994
Tongue
German
Weight
896 KB
Volume
77
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Use of the 2-dansylethoxycarbonyl (= 2-{[5-(dimethylan1ino)naphthalen-I-yl]sulfonyl}ethoxycarbonyl; Dnseoc) group as an intermediate 5'-OH protecting group in oligodeoxyribonucleotide synthesis using the automated phosphoramidite approach is described in a model study to an alternative strategy in RNA synthesis.

📜 SIMILAR VOLUMES

Nucleotides. Part L. Aglycone protection
Nucleotides. Part L. Aglycone protection by the (2-dansylethoxy)carbonyl (= {2-{[5-(dimethylamino)naphthalen-l-yl]sulfonyl}ethoxy}carbonyl; dnseoc) group a new variation in oligodeoxyribonucleotide synthesis
✍ Thomas Wagner; Wolfgang Pfleiderer 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 German ⚖ 889 KB

The (2-dansylethoxy)carbonyl( = { 2-{ [5-(dimethylamino)naphthalen-l-yl]sulfonyl}ethoxy}carbonyl; dnseoc) group was employed for protection of the amino functions of the aglycone residues. The lactam function of 2.'-deoxyguanosine was on the one hand unprotected and on the other hand alkylated at O6