Nucleotides, Part LXVI , β-Heteroarylethyl Groups – New Phosphate-Protecting Groups for Phosphotriester Chemistry

Nucleotides, Part LXVII , The 2-Cyanoeth

Nucleotides, Part LXVII , The 2-Cyanoethyl and (2-Cyanoethoxy)carbonyl Group for Base Protection in Nucleoside and Nucleotide Chemistry

✍ Claudia Merk; Tilman Reiner; Evgeny Kvasyuk; Wolfgang Pfleiderer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 246 KB

The amino functions of the common 2'-deoxyribo-and ribonucleosides were blocked by the (2cyanoethoxy)carbonyl group on treatment with 2-cyanoethyl carbonochloridate (5) or 1-[(2-cyanoethoxy)carbonyl]-3-methyl-1H-imidazolium chloride (6) leading to 7, 18, 8, 19, 9, and 20. In 2'-deoxyguanosine, the a